The 57-year-old Nine Inch Nails frontman acknowledges that his exit from the app was all but sealed before Elon Musk's $44 billion acquisition of the social networking platform.
"We don't need the haughtiness of the billionaire class to feel like they can just go in and solve everything," he told The Hollywood Reporter.
"I simply find that it has turned into such a toxic environment, even without him involved. I need to unwind for the sake of my mental health. I no longer feel comfortable being there.
Kanye West, meanwhile, came back to Twitter over the weekend.
The 45-year-old rapper was banned from the microblogging service, which billionaire businessman Elon Musk acquired late last month, after he made a number of anti-Semitic remarks. However, his account was reinstated in early November, and he has since resumed tweeting.
He posted: "Testing Testing Seeing if my Twitter is unblocked" on Sunday, 20.11.22. (sic)
The 'Stronger' hitmaker, who previously wed Kim Kardashian and shares five children with the reality star (North, 9, Saint, 6, Psalm, 4, and 3-year-old Chicago), had earlier tweeted that he was "going death con 3 on Jewish people" and earlier stirred up debate by donning a White Lives Matter t-shirt during Paris Fashion Week.
Kanye's return was authorised before Musk, the inventor of Tesla, claimed in the past.
He explained at first: "A content moderation council with a wide range of perspectives will be created by Twitter. Before that council meets, no significant content decisions or account reinstatements will be place. (sic)."
After being barred from the platform permanently in January 2021 as a result of the attack on the US Capitol in Washington, D.C., where Trump supporters stormed the building as votes were being counted to confirm Joe Biden's victory, Kanye posted a tweet just hours later announcing the reinstatement of Trump.
Tweeted by Musk: "The conversation is over. Trump will get his job back. People Before God."
The 75-year-old businessman's @RealDonaldTrump account went back live shortly after, but he hasn't tweeted since the restriction was removed.